1. Home
  2. Universitat de Barcelona
  3. Departament de Biomedicina
  4. Browsing Departament de Biomedicina by Title

Browsing Departament de Biomedicina by Title

Now showing items 1-20 of 41

    Aberrant TIMP-1 regulation in tumor-associated fibroblasts by the TGF-β1/SMAD3 pathway in lung cancer: implications in tumor progression and resistance to antifibrotic therapies 

    Duch Gili, Paula (Date of defense: 2022-03-14)

    Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression is poorly defined. ...

    Cerca i identificació de nous biomarcadors de fibrosi hepàtica per mitjà de tècniques proteòmiques 

    Marfà Bruix, Santiago (Date of defense: 2017-02-24)

    La detecció precoç de fibrosi hepàtica és de gran rellevància per al diagnòstic i el tractament dels pacients amb una malaltia hepàtica crònica. Actualment, s'utilitzen diversos procediments per a la seva estadificació. ...

    Characterization of the in vivo immunomodulatory properties of CD5 and CD6 

    Simões, Inês Tadeu dos Anjos (Date of defense: 2017-09-14)

    Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- Rich superfamily, ...

    Cholesterol and StARD1: a common nexus in Alcoholic Liver Injury and Niemann-Pick Type C disease-associated mitochondrial stress 

    Solsona i Vilarrasa, Estel (Date of defense: 2021-03-22)

    [eng] Cholesterol accumulation in mitochondrial membranes is a common feature of various chronic diseases, such as cardiovascular disease, cancer, and Alzheimer's as well as liver diseases. Studies prior to this doctoral ...

    Comparative study of nanocarriers targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes 

    Loeck, Maximilian (Date of defense: 2022-09-16)

    [eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised by deficiency of ...

    Dual role of CDK5 on cognitive deficits and striatal vulnerability in Huntington’s disease 

    Alvarez Periel, Elena (Date of defense: 2018-07-06)

    Huntington’s disease (HD) is a neurodegenerative disorder caused by an autosomic mutation on the Huntingtin (HTT) coding gene. HD is mainly characterized by the appearance of motor symptoms or choreas, which are associated ...

    Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells 

    Duran Güell, Marta (Date of defense: 2023-04-12)

    [eng] Albumin exerts pleiotropic actions beyond its oncotic power, which include binding, transport and detoxification of endogenous and exogenous molecules, antioxidant activity and the modulation of immune and inflammatory ...

    El paper de p27 a la regulació de la via de Notch 

    Durán Rodríguez, Rodrigo (Date of defense: 2022-01-28)

    Partint dels resultats previs obtinguts per aquest grup d’investigació, es planteja la següent hipòtesi de treball: “La proteïna p27 és un regulador de la via de Notch. Aquesta regulació es realitzaria, principalment, ...

    Estimació del risc de neoplàsia colorectal avançada a partir de la quantificació de l’hemoglobina fecal en el cribratge del càncer de còlon i recte 

    Augé Fradera, Josep Maria (Date of defense: 2017-05-26)

    INTRODUCCIÓ: A nivell mundial el càncer de còlon i recte (CCR) és el segon i el tercer en freqüència en homes i en dones, respectivament. La seva història natural és coneguda, se sap que habitualment es desenvolupa a ...

    Evaluación funcional del péptido EAR-20 como posible agonista de los receptores ionotrópicos de glutamato de tipo NMDA 

    García Díaz, Roberto (Date of defense: 2023-05-26)

    [spa] Debido a la importancia de la modulación del NMDAR, en el grupo de investigación de proteínas (GRIP) se han diseñado una serie de péptidos derivados de la Conantokina-G (Con-G), un péptido antagonista de los NMDARs, ...

    Evaluation of therapeutic targets for the treatment of behavioral alterations and neuropathology in Huntington’s disease. The role of histone deacetylase 3 and p75 neurotrophin receptor 

    Suelves Caballol, Núria (Date of defense: 2018-07-23)

    Huntington’s disease (HD) is a rare genetic disorder caused by an aberrant expansion of a CAG trinucleotide in the huntingtin gene (Htt). The neuropathology of the disease is characterized by progressive neuronal dysfunction ...

    Exploring extracellular small RNAs as potential early biomarkers and mediators in the pathogenesis of Huntington’s disease 

    Herrero Lorenzo, Marina (Date of defense: 2024-10-18)

    [eng] Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expansion of CAG triplets in the huntingtin gene (HTT). The main neuropathological signs of HD include the presence of ...

    Funció de la MAPKAP quinasa Srkl en resposta a pertorbacions del citoesquelet d'actina en Schizosaccharomyces pombe 

    Llanes Velasco, Julia (Date of defense: 2020-09-16)

    A Schizosaccharomyces pombe, la citocinesi està mediada per l’assemblatge i la constricció de l’anell contràctil d’actomiosiona. Pertorbacions petites en aquesta estructura activen un conjunt de mecanismes de control que ...

    Implications of astrocytic RTP801 in neuroinflammation and neurodegeneration in Alzheimer’s disease 

    Chicote González, Almudena (Date of defense: 2024-11-29)

    [eng] The central nervous system (CNS), consisting of the brain and spinal cord, is supported by various cells including neurons, glial cells, and blood vessel cells. Neurons are responsible for transmitting signals, while ...

    Inhibition of KRAS oncogenic activity by interfering with new KRAS interactors 

    Abuasaker, Baraa (Date of defense: 2024-06-14)

    [eng] INTRODUCTION: The Kirsten rat sarcoma oncogene (KRAS) homologue stands out as a prominent oncogene, distinguished by its notably elevated mutation rate compared to other oncogenes. This genetic anomaly is intricately ...

    Investigating therapeutic targeting to intercellular adhesion molecule 1 through epitope, isoform, and cross-reactivity selection 

    Vigo, Marco (Date of defense: 2024-09-26)

    [eng] AIM AND HYPOTHESIS: Based on the previous literature and indicated gaps of knowledge, the hypothesis for this study was that by generating cell lines expressing only specific forms of ICAM-1, it may be possible to ...

    Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington’s Disease 

    Rodríguez Urgellés, Ened (Date of defense: 2022-01-20)

    Huntington’s Disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is caused by an unstable expansion of the CAG trinucleotide ...

    Machine Learning for predicting Immunotherapy response from routine Medical Imaging 

    Ligero Hernández, Marta (Date of defense: 2024-03-15)

    [eng] HYPOTHESIS: Precision oncology has revolutionized the landscape of cancer treatment. Emerging therapeu- tic approaches, such as immunotherapy or anti-angiogenic agents, have exhibited remarkable outcomes in solid ...

    Mecanismes neuronals de la picor aguda i crònica en neurones sensorials: implicació del canal TRESK 

    Andrés Bilbé, Alba (Date of defense: 2020-11-13)

    [cat] TRESK (K2P18.1) és un canal de potassi de fuga que s’expressa en algunes subpoblacions de neurones sensorials, on modula el potencial de membrana en repòs, la descàrrega de potencial d’acció i l’excitabilitat neuronal. ...

    Membrane Trafficking of TGF-β and Transcriptome Analysis in Marfan Syndrome 

    Siegert, Anna-Maria Elisa (Date of defense: 2017-10-20)

    Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that affects between 1.5 and 17.2 in 100.000 live births. MFS is caused by mutations in the extracellular matrix (ECM) glycoprotein ...