Facultat de Farmàcia i Ciències de l'Alimentació: Enviaments recents
Ara mostrant els elements 141-160 de 338
Estudi d’incorporació i alliberament de fàrmacs amb noves formes de dosificació basades en sistemes micro-nanoestructurats
Els materials porosos polimèrics, també denominats escumes sòlides, són materials sòlids de baixa densitat i elevat volum de porus. Són ben coneguts per la seva varietat d’aplicacions i constitueixen una part integral de ...
Sueño y ritmos circadianos en la pérdida de peso en pacientes con obesidad grave sometidos a cirugía bariátrica
Hasta hace no muchos años la obesidad se relacionaba con un desequilibrio entre la ingesta dietética y el gasto energético. Sin embargo, esta aproximación era muy simplista y actualmente se conoce el carácter multifactorial ...
Caracterización de las vesículas de membrana de Shewanella vesiculosa M7(T)
La presente Tesis Doctoral se enmarca en el proyecto CTQ2014-59632-R concedido por el ministerio de economía y competitividad al grupo de investigación. El trabajo se ha centrado en caracterizar las vesículas de membrana ...
Exploring molecular mechanisms of key targets in metabolic and infectious diseases
This doctoral thesis is focused on disclosing molecular factors that regulate the functional mechanism of key targets in i) metabolic disorders, such as diabetes and obesity, and ii) tuberculosis (TB). These diseases have ...
Polyamine metabolism during the defense response to Pseudomonas syringae in Arabidopsis thaliana
The topic of this thesis is to investigate the polyamine metabolism during defense response in Arabidopsis thaliana. I mainly focused on the alteration of polyamine metabolism in different layers of plant immunity triggered ...
Characterization of the functional connection between the BROMODOMAIN and EXTRATERMINAL DOMAIN PROTEIN 9 (BET9) and the circadian clock in Arabidopsis thaliana
The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing organisms to anticipate ...
Altered Levels of Glycosylated Sterols Affect Tomato Development and Stress Response
Los esteroles son una familia de compuestos triterpénicos que se presentan en forma libre (FS, por sus siglas en inglés) o conjugada, como ésteres (SE), glicósidos (SG) y acilglicósidos de esteroles (ASG). Los esteroles ...
Design and synthesis of new potentially inhibitors of PCSK9 and KRAS proteins
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major cause of deaths in ...
Biophysical Techniques for the Investigation of Protein-Ligand Complexes
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several stages. In this ...
Application of computational docking to the characterization and modulation of protein-protein interactions of biomedical interest
The study of the 3D structural details of protein interactions is essential to understand biomolecular functions at the molecular level. In this context, the limited availability of experimental structures of protein-protein ...
Development of crystallographic methods for phasing highly modulated macromolecular structures
Pathologies that result in highly modulated intensities in macromolecular crystal structures pose a challenge for structure solution. To address this issue two studies have been performed: a theoretical study of one of ...
Targeting strategies against Plasmodium and practical applications: blocking parasite development with heparin derivatives and identifying new aptamers for diagnosis
La malaria es una enfermedad infecciosa producida por Plasmodium, protozoo transmitido a través de la picadura de mosquitos del género Anopheles. Aunque existen tratamientos y medidas de prevención, en los países tropicales ...
New antimicrobial strategies against bacterial infections
Bacterial infections are a major health concern worldwide due to the mortality and comorbidity associated levels. Besides the development of drug-resistance mechanisms, most recalcitrant infections are caused by bacteria ...
Heterogeneity of carcinoma-associated fibroblasts and REV-ERB-induced phenotype molding in pancreatic ductal adenocarcinoma
Tumor-stroma crosstalk is essential for PDAC formation. Therefore, the stroma, and specifically the carcinoma-associated fibroblasts (CAFs), are the target of therapeutic alternatives to treat highly desmoplastic tumors ...
New insights into RANK signaling pathway in the mammary gland
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive inhibitor that ...
Structural analysis of macromolecular folds and the application to phasing
Determining and understanding protein structure in atomic detail is a fundamental process to the advancement of biotechnology and biomedicine, shedding light the role of macromolecules and their complexes, their biological ...
Human Primary Organoid-Derived Epithelial Monolayers as a Novel Strategy for the Study of Adherent Invasive Escherichia coli pathogenicity and the effects of Postbiotics on Intestinal Epithelial Function
Inflammatory bowel disorders – such as Inflammatory Bowel Disease (IBD) – are rising worldwide. A well-known feature of IBD is dysbiosis of the gut microbiota, characterized by a significant reduction of beneficial strains ...
Novel Quatsome nanovesicles, prepared using CO2, for the development of advanced nanomedicines
Quatsomes are lipid-based nanovesicles developed by Nanomol group, composed of ionic surfactants and sterol derivatives. Regarding their properties, Quatsomes have shown to be highly homogenous and stable for years, important ...
Structural and functional analysis of Zika Virus NS5 protein
Zika virus (ZIKV) belongs to the Flaviviridae family and constitute an important public health concern since ZIKV infection produced devastating effects in new born infants. Flaviviruses present a positive sense single ...
Funció i potencial terapèutic de CPEB4 en l’aparició i progressió de lesions hepàtiques en context d’obesitat
El carcinoma hepatocel·lular (HCC) és la segona causa de mort relacionada amb càncer i té avui en dia opcions terapèutiques molt limitades. Tot i que el HCC s’acostuma a estudiar en estats de malaltia hepàtica molt avançats, ...
