Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 241-260 of 338
Sistemas miméticos de los cuerpos laminares epidérmicos para el tratamiento de la piel
El estrato córneo (SC) es la capa más superficial de la epidermis. Su función es actuar como barrera, evitando la pérdida de agua y la entrada de microorganismos. El SC está formado por corneocitos rodeados por lípidos que ...
Epidemiology and control of canine leishmaniosis: characterization of a previously undescribed endemic area in Catalonia and CaniLeish® vaccine field trial
Leishmaniosis is an important vector-borne zoonosis caused by Leishmania infantum. The disease is widespread across several continents and endemic in the Mediterranean region. The domestic dog is the main vertebrate reservoir ...
Noves estratègies en la prevenció de la lesió hepàtica per isquèmia reperfusió = New strategies in the prevention of liver ischemia reperfusion injury
Avui en dia, la única solució per a pacients que es troben en una situació de fase terminal de malaltia hepàtica o en una lesió hepàtica aguda es el transplantament. La demanda d’òrgans per a aquesta finalitat supera ...
Nova preparació pediàtrica per al tractament de la tuberculosi
La tuberculosi és una infecció bacteriana causada per un micobacteri anomenat Mycobacterium tuberculosis. Actualment és la primera causa mundial de mortalitat causada per un agent infecciós fins i tot per sobre de la ...
Bacteriófagos en el cuerpo humano
Los bacteriófagos son componentes abundantes y omnipresentes en muchos ambientes naturales, y el cuerpo humano no es la excepción. Del mismo modo que pasa en la naturaleza, los fagos en el cuerpo humano pueden desempeñar ...
Diseño y caracterización de nanopartículas poliméricas de Epigalocatequina-3-galato para el tratamiento de enfermedades del sistema nervioso central
Las enfermedades del sistema nervioso central (SNC) engloban a un conjunto de patologías de elevada gravedad debido a la importancia de este sistema para el organismo. La Epilepsia del Lóbulo Temporal (TLE) y la Enfermedad ...
Estudios in vitro, ex vivo e in vivo de formulaciones de pranoprofeno para administración ocular
El presente trabajo de investigación versa sobre la caracterización in vitro, ex vivo e in vivo de dos sistemas nanoestructurados de liberación sostenida (PF-F1NPs y PF- F2NPs) conteniendo pranoprofeno (PF) como principio ...
Caracterització funcional de LOXL2 en el rabdomiosarcoma alveolar
El rabdomiosarcoma (RMS) és el sarcoma de parts toves més comú en nens i adolescents que representa un 3-4 % dels càncers infantils. En canvi, és molt menys freqüent en adults. Principalment consisteix en dues variants ...
Analysis of the molecular function of kazrin in endosomal trafficking
Endocytosis and endosomal trafficking are of central meaning in all eukaryotic cells. It enables cells to rapidly modify their surface exposure of signalling complexes, nutrient and ion transporters, to maintain the ...
The Role of Protein Kinase N in Gastric Cancer
Gastric cancer (GC) is one of the most common types of cancer in the Western World and accounts for over 700,000 deaths every year worldwide. The prognosis is dismal, with an average 5-year survival rate of less than 20%, ...
Dual effect of Semaphorin 4D blockade in neuroendocrine tumor malignization: from vessels to macrophages
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its therapeutic targeting ...
Immunoreceptor MerTK: A journey from the membrane into the nucleus of human dendritic cells
Discrimination between foreign and potentially harmful antigens, and the body’s own tissue is one of the most crucial first steps that lays at the basis of a proper immune response. Immunoreceptors are cell membrane embedded ...
Recerca i caracterització de nous "leads" per al tractament del càncer
La present tesi doctoral està enfocada al desenvolupament de noves petites molècules dirigides a diferents dianes del càncer. Els descobriments recents sobre la seqüenciació genòmica del càncer han revelat que molts dels ...
RANK signaling in mammary spontaneous tumorigenesis and tumor-stromal crosstalk
The discovery that RANK signaling mediates the protumorigenic role of progesterone in the mammary gland and its association with poor prognosis in breast cancer has opened the possibility of using RANKL inhibitors for ...
CPEB4 function in macrophages
As innate immune cells, macrophages sense endogenous and exogenous danger signals and respond orchestrating inflammatory processes. For the rapid induction and efficient resolution of inflammatory responses, macrophages ...
Molecular basis of p38a MAPK signaling
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate different ...
Síntesis de nuevos compuestos con potencial actividad antitumoral y/o antiinflamatoria
Esta tesis doctoral está enfocada a la investigación de nuevos agentes con potencial actividad antiinflamatoria y antitumoral mediante la inhibición de enzimas básicas para la progresión de la inflamación como la ciclooxigenasa ...
Phase Combination and its Application to the Solution of Macromolecular Structures: Developing ALIXE and SHREDDER
Phasing X-ray data within the frame of the ARCIMBOLDO programs requires very accurate models and a sophisticated evaluation of the possible hypotheses. ARCIMBOLDO uses small fragments, that are placed with the maximum ...
Molecular mechanism of dBigH1 action
INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...
Water-in-Water Emulsions for Obtaining Enzyme-Loaded Microgels and Encapsulated Emulsions
Encapsulation of enzymes into protective matrices is of interest in drug delivery or industrial processes, to control the release of the enzyme or protect it from harsh environments. We are studying the encapsulation of ...
