Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 301-320 of 338
Fatty Acids in Obese Pregnancies: Maternal and Child Outcomes
Maternal obesity has implications on the health of future generations by early life programming. The mother is usually the main source of nutrients for the fetus and neonate, hence her nutritional status is crucial for ...
Investigating the genetic component of Parkinson’s disease through the use of human induced pluripotent stem cells and gene editing
Despite the advances in the identification of genes and proteins involved in Parkinson’s disease (PD), there are still appreciable gaps in our understanding of the mechanisms underlying the chronic neurodegenerative process ...
Efectos de la depleción de la histona H1 en células de cáncer de mama: proliferación y respuesta a interferón
La histona H1 se une al nucleosoma, situándose en la base, cerca de los sitios de entrada y salida del DNA, siendo una de sus principales funciones descritas, el mantenimiento de una estructura estable y condensada de la ...
Arming Oncolytic Adenoviruses with Transgenes to Engage Stroma Toxicity and Immune Stimulation as a Double Strategy Against Cancer
Oncolytic virotherapy with Adenoviruses has regained importance in the past years with the appearance of fresh and promising strategies to deal with tumors. Among the major limitations of this therapy are the immune ...
Study of the Influence of a Combination of Pharmacogenetic Variables on Tacrolimus Exposure: A Population Pharmacokinetic Approach
The calcineurin inhibitor Tacrolimus (Tac) is used to prevent acute rejection after renal transplant. Unfortunately, the clinical use of Tac is complicated by its considerable toxicity, narrow therapeutic window, and high ...
Disseny, síntesi i avaluació biològica de nous compostos potencialment antitumorals per inhibició enzimàtica
Aquesta tesis doctoral està enfocada a la investigació de nous agents amb potencial activitat antitumoral, mitjançant la inhibició d'enzims claus per al desenvolupament i la progressió del càncer, com per exemple KRAS. De ...
Micro- and nanomaterials for drug delivery in skin diseases
anostructured supramolecular hydrogels and gold nanoparticles, as two kinds of nanomaterials, were synthsized, characterized and evaluated for their potential as drug delivery systems. Two bis-imidazolium cationic ...
Risk and benefits of beer and nonalcoholic beer moderate consumption on cardiovascular system
Beer is by far the most widely consumed alcoholic beverage in the world. Moderate alcohol consumption in general has been inversely associated with incident cardiovascular disease in observational studies. However, it has ...
Nuevas aproximaciones terapéuticas para la regeneración muscular basadas en el ejercicio físico, plasma rico en plaquetas (PRP) y glicosaminoglicanos en modelo de rata
Las lesiones del músculo esquelético son las lesiones más comunes en el ámbito deportivo (su frecuencia puede variar del 10-55%), siendo una preocupación importante en la medicina deportiva. Más del 90% de todas las lesiones ...
Los sistemas personalizados de dosificación y su aportación a la seguridad de los pacientes
Los Sistemas Personalizados de Dosificación (SPD) son un sistema de reacondicionado donde el farmacéutico organiza los medicamentos de forma farmacéutica sólida que toma un determinado paciente durante una semana, siguiendo ...
Synthesis and optimization of new sphingolipid sensors for metabolism and trafficking studies
Over the past decade, sphingolipids have emerged as a new class of modulators of various cell functions. Ceramide, which is the central molecule in the biosynthesis of sphingolipids and glycosphingolipids, is involved in ...
New strategies for improving the biotechnological production of pharmaceuticals and biopharmaceuticals in plant cell and organ cultures
The thesis is presented as a compendium of publications and includes six different sections: General Introduction, Objectives, Results, General Discussion, Conclusions and References. The General Introduction summarizes ...
Connection between viral genetic diversity and clinical manifestation of Papillomavirus infection = Connexió entre la diversitat de genotips virals i les manifestacions clíniques de la infecció pel virus del Papil·loma
Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides only limited protection ...
Síntesi de nous compostos policíclics com a possibles precursors d’alquens piramidalitzats
En la present Tesi Doctoral s’ha desenvolupat una metodologia sintètica per accedir a compostos policíclics complexos funcionalitzats de manera senzilla i eficaç, amb l’objectiu de poder generar a partir d’aquests un alquè ...
Prions i Agregons com a Inhibidors de Start: una Via a l’Envelliment Cel·lular
Saccharomyces cerevisiae és un model escaient per estudiar el procés d’envelliment a nivell cel.lular gràcies al seu mecanisme de divisió asimètrica. Fent una analogia amb l’envelliment en organismes superiors, on les ...
Insight into the structure and function of engineered biocatalysts: serine hydroxymethyltransferase from Streptococcus thermophilus and halohydrine dehalogenase D2 from Gammaproteobacterium
The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth of structural information ...
El problema de la no iniciación del tratamiento farmacológico: evaluación con métodos cuantitativos
La no iniciación es un comportamiento que se caracteriza por no empezar aquellos tratamientos farmacológicos prescritos por primera vez. Este comportamiento puede estar influenciado por distintos factores y parámetros ...
Role of PI3K in pericytes during angiogenesis
Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. Therefore, advancing ...
Estudio del valor pronóstico de SERPINA E1 y su papel en el crecimiento y la diseminación metastática del carcinoma escamoso de cabeza y cuello
En múltiples tipos tumorales, SERPINA E1 se asocia con una peor evolución clínica de los pacientes. En el carcinoma escamoso de cabeza y cuello (CECC), el aumento del nivel de expresión de SERPINA E1 por parte de las células ...
Chronobiological related factors and weight loss evolution in severe obese patients undergoing bariatric surgery
Currently, the most effective treatment for severe obesity resulting in a large and marked weight loss is bariatric surgery (BS) (Courcoulas, AP et al. 2013).However, several studies have shown that weight loss outcomes ...
