Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 61-80 of 336
Dissecting the cellular basis of Inflammatory Bowel Disease through Single-cell RNA sequencing
[eng] Crohn’s disease and ulcerative colitis are chronic inflammatory bowel diseases that show perplexing heterogeneity which is poorly understood at a cellular level. We applied single-cell RNA sequencing and CosMxTM ...
Formación y caracterización de sistemas terapéuticos a partir de emulsiones agua-en-agua
[spa] Las emulsiones W/W son dispersiones de dos fases acuosas inmiscibles, que presentan la compartimentalización multifásica de las emulsiones convencionales sin requerir la presencia de solvente orgánico ni tensioactivo ...
Effect of moderate beer consumption on post-menopausal women's health. New insights towards more comprehensive nutritional research and a personalitzed nutrition perspective
[eng] Beer is one of the most widely consumed alcoholic beverages in the world and has been crafted for many years, while the enhancement of post-menopausal women’s health through the bioactive compounds of this beverage ...
Estudi de les funcions reguladores de les regions transcrites ultraconservades (T-UCRs) sobre l’expressió gènica
[cat] Els RNAs no codificants tenen un paper important com a reguladors de les funcions biològiques del desenvolupament i la fisiologia, i per tant la seva desregulació pot tenir un impacte en diverses patologies. Estan ...
Mapping protein aggregation by deep mutational scanning
[eng] Proteins can adopt multiple conformations and material states, from soluble states to self- assemblies, such as liquid condensates or amyloids. Protein aggregation has been associated with many human diseases but how ...
Mecanismos de resistencia a terapias dirigidas contra BRAF(V600E) y estudio de nuevas combinaciones de fármacos en cáncer de colon
[spa] Alrededor del 10% de los pacientes con cáncer colorrectal metastático (mCRC) presentan la mutación BRAF(V600E), mutación que está asociada a una peor respuesta al tratamiento estándar con agentes quimioterapéuticos ...
Technological developments in Virtual Screening for the discovery of small molecules with novel mechanisms of action
[eng] Advances in structural and molecular biology have favoured the rational development of novel drugs thru structure-based drug design (SBDD). Particularly, computational tools have proven to be rapid and efficient tools ...
Child behavior, feeding practices, and health in the context of obesity
[eng] Childhood obesity is a global public health problem with aggravating consequences during adulthood, including cardiovascular disease, type 2 diabetes, musculoskeletal disorders, and some types of cancers. The reason ...
Fatty acids and antioxidants in older adults with visual impairment: A contribution to Healthy Ageing
[eng] This research aims to study the effect of supplementation with docosahexaenoic acid (DHA) and antioxidants in older adults diagnosed with age-related macular degeneration or cataracts to contribute to preventive ...
Development and characterization of solid lipid nanoparticles (SLN) as a vehicle of biomolecules
[eng] The interest of this work was to manufacture solid lipid nanoparticles that serve as a vehicle for biomolecules, specifically Chondroitin sulfate and pEGFP plasmid DNA. In the experimental part, the reagents and ...
Unraveling the Fundamental Aspects of Enzyme-powered Micromotors
[eng] Enzyme-powered motors are based on the micro- and nanosized particles that propel thanks to the chemical conversion of enzymes attached on their surface. Recently, these tiny devices have been applied for a plethora ...
Galenic development of a new sunscreen product for skin cancer prevention
[eng] Sunscreen application is one of the best methods to prevent erythema, keratogenic cancer, melanoma and premature skin ageing. UV filters are the active substances preventing the harmful effects. Commercial UV filters ...
Discovery of First-In-Class inhibitors of a DNA damage repair pathway
[eng] Cancer is the second leading cause of death globally. The gold standard for cancer has historically been surgery, radiotherapy and chemotherapy. Although the efficacy of chemotherapy has been broadly confirmed, drug ...
Efecto de la Dieta Mediterránea sobre los patones de tratamiento farmacológico en adultos con alto riesgo cardiovascular
[spa] Las enfermedades cardiovasculares (ECV), representan la principal causa de morbimortalidad en los países desarrollados y su aumento continúa a nivel mundial. Su denominación hace referencia a varias enfermedades de ...
BasC K154 role on cytosolic gate closing. The bacterial alanine-serine-cysteine transporter as a model
[eng] L-type amino acid transporters play key roles in human physiology and are involved in several human pathologies such as primary inherited aminoacidurias (Feliubadaló et al., 1999; Torrents et al., 1999), autism ...
Determinants de pèrdua de pes en persones amb obesitat intervingudes amb tècniques bariàtriques endoscòpiques. Desenvolupament i validació d’un nou qüestionari curt d’hàbits saludables d’alimentació i d’activitat física
[cat] Les teràpies endoscòpiques bariàtriques (TEB) són estratègies prometedores per al tractament de l'obesitat. No obstant això, hi ha una gran variabilitat en la pèrdua de pes i els individus sovint recuperen el pes ...
Identification and characterisation of transcriptional regulators through proximity interaction mapping in two distinct systems
[eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different transcriptional ...
Dietary (poly)phenols intake and cardiometabolic health in adolescents from Spain
[eng] The rising of cardiometabolic risk factors like obesity, higher blood pressure, and alteration in the metabolism of lipids and glucose during adolescence increase the risk of type 2 diabetes mellitus and cardiovascular ...
Desarrollo de sistemas nanoestructurados conteniendo Lactoferrina para el tratamiento de patologías oculares
[spa] La inflamación ocular es uno de los trastornos oftalmológicos más comunes y está asociada a un amplio abanico de patologías que afectan tanto al segmento anterior como posterior del ojo. El síndrome del ojo seco (SOS) ...
Effect of Cpt1a deletion in the mediobasal hypothalamus in response to physical activity and aging
[eng] Food intake and energy homeostasis are tightly regulated by the brain through a complex neuronal network located in the hypothalamus. Within this region, the mediobasal hypothalamus (MBH) acts as an interface between ...
