Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 81-100 of 338
Desarrollo de sistemas nanoestructurados conteniendo Lactoferrina para el tratamiento de patologías oculares
[spa] La inflamación ocular es uno de los trastornos oftalmológicos más comunes y está asociada a un amplio abanico de patologías que afectan tanto al segmento anterior como posterior del ojo. El síndrome del ojo seco (SOS) ...
Effect of Cpt1a deletion in the mediobasal hypothalamus in response to physical activity and aging
[eng] Food intake and energy homeostasis are tightly regulated by the brain through a complex neuronal network located in the hypothalamus. Within this region, the mediobasal hypothalamus (MBH) acts as an interface between ...
Unveiling the therapeutic potential of THC in endometrial cancer
[eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported autophagy pathway ...
CPT1AM overexpression in BAT from HFD-treated mice prevents the induction of obesity and associated diabetes
[eng] Obesity and its associated metabolic diseases are currently a priority research topic. The increase in global prevalence at different ages is having a huge economic and health impact. Genetic and environmental factors ...
Development and application of in-vitro assays for the study of the biological activity of pharmaceutical products
[eng] This industrial Ph.D. thesis aimed to illustrate the presence of the cell-based bioassays throughout the whole life of a drug product and to demonstrate its importance for a complete characterization of a pharmaceutical ...
Targeting Plasmodium falciparum protein aggregation as a new antimalarial design strategy
[eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is insufficient to ...
Nutritional management of Myotonic Dystrophy type 1
[eng] Myotonic dystrophy type 1 (DM1), one of the more complex diseases already known, is the most common and multisystemic rare neuromuscular disease among adults, without cure and limited pharmacological treatments. In ...
Desarrollo y optimización de parches transdérmicos tipo "Drug in Adhesive" de ropinirol de base acrílica mediante un dispositivo laminador de vertido sobre molde (Mold-Casting) diseñado en 3D
[spa] En esta tesis doctoral se realizan el desarrollo, estudio y optimización de parches transdérmicos de base acrílica de tipo "drug in adhesive" de ropinirol para su aplicación tópica en el tratamiento de la enfermedad ...
Identifying new targets to inhibit brat tumour growth in Drosophila melanogaster through combined transcriptomics and functional genome-wide analysis
[eng] I have used the brain tumours that originate in Drosophila larvae upon depletion of the brain tumor (brat) gene as a model to study neoplastic malignant growth. I have used genetic analysis to interrogate the Drosophila ...
Proteína inmunodominante P116 del patógeno humano Mycoplasma pneumoniae: un recipiente para el colesterol y otros lípidos esenciales
[spa] Mycoplasma pneumoniaees una bacteria patógena humana sin pared celular que causa neumonías atípicas y otras infecciones respiratorias. Es una de las pocas especies de procariotas que necesitan lípidos en la integridad ...
New insights into the association between carotenoids, polyphenols and vitamin A, and highly prevalent diseases
[eng] The present dissertation aims at broadening current knowledge regarding the importance of bodily or tissue status of bioactive compounds that are highly abundant in the Mediterranean diet (carotenoids and polyphenols) ...
Metabolic vulnerabilities of rhabdomyosarcoma: insights into the role of ASS1
[eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal translocation. ...
Efecto “HALO” de una intervención de pérdida de peso mediante cambios en el estilo de vida en familiares de individuos con sobrepeso y/u obesidad. Validación de un cuestionario de adherencia a Dieta Mediterránea hipocalórica
[spa] La obesidad es una enfermedad crónica y un problema de salud pública, producido por un desequilibrio entre la ingesta y el gasto de energía. La prevalencia de la obesidad en todo el mundo se ha duplicado desde 1980, ...
Design and characterization of topical ketorolac tromethamine formulations
[eng] Pain and inflammation are the most common and recurrent side effects after surgery and, understandably, the patient's most feared, affecting treatment adherence. The present work aims to characterize in vitro, ex ...
Synthetic approaches towards organic products of pharmaceutical interest
[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are very old, therefore ...
Characterization of the proteome and palmitoylome alterations induced by palmitic and oleic acids in OSCC cells
El papel que juega el metabolismo lipídico en la progresión del cáncer está siendo revisado. Estudios recientes de nuestro laboratorio demuestran que el tratamiento con ácido palmítico (AP) de células en cultivo o ...
Biomarkers and therapeutic targets based on bacterial “Quorum Sensing” system
Infectious diseases are still one of the main leading causes of death worldwide mainly due the overuse and the lack of development of new antibiotics. This fact has increased the appearance of multidrug resistance (MDR) ...
Data integration in inflammatory bowel disease
INTRODUCTION: Inflammatory bowel disease is a complex intestinal disease with several genetic and environmental factors that can influence its course. The ethiology and pathophysiology of the disease is not fully understood. ...
Structure-based drug design of novel antiviral compounds against human herpesvirus and coronavirus
The herpesvirus diseases are increasing in importance as a public health problem throughout the world. Members of the human herpesvirus family are global in distribution and infect 60-95% of the world's population, both ...
Computational and biophysical approaches for the discovery of Tribbles pseudokinases modulators
Tribbles (TRIB) homologues proteins are a family of three pseudokinases withan important role in controlling immunity, metabolism, and cancer throughprotein-protein interactions (PPIs). TRIB pseudokinases have the same ...
