Facultat de Farmàcia i Ciències de l'Alimentació: Envíos recientes
Mostrando ítems 101-120 de 338
Photoswitchable ligands targeting beta-adrenoceptors for in vitro, in vivo and structural studies
G protein-coupled receptors (GPCRs) are a large family of membrane proteins responsible for signaling transduction processes. Due to their roles in modulating essential physiological functions, GPCRs are classical ...
Epigenetic Dysregulation of Monocytes as a Sensor of Activity and Progression in Arthritis
OBJECTIVE: Identifying predictive biomarkers at early stages of undifferentiated arthritis (UA) is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely associated with ...
LIF as a metabolic messenger: study of glucose sensing by NSCLC and LIF-mediated nutrient stress responses
Tumours grow in a self-imposed hypoglycaemic microenvironment due to their exacerbated metabolic needs. To thrive in these harsh conditions, malignant cells must adapt their own metabolic routes and hijack the host nutrient ...
Influencia del tipo de lípidos de la nutrición parenteral sobre la retinopatía de la prematuridad
INTRODUCCIÓN. La retinopatía de la prematuridad (Retinopathy of prematurity, ROP) es una vitreorretinopatía proliferativa que afecta a los recién nacidos prematuros y es una de las principales causas de ceguera infantil. ...
Procesamiento de los receptores TAM en patología humana y su empleo como biomarcadores
La familia TAM consta de tres receptores de membrana de tipo tirosina-quinasa: TYRO3, AXL, MERTK. Sus ligandos son Growth Arrest-Specific 6 (GAS6) y la Proteína S (PROS1). Éstas últimas son proteínas dependientes de vitamina ...
Nutritional and body composition changes affecting head and neck cancer patients during oncological treatment
The use of imaging techniques routinely used for diagnosis and the assessment for treatment response in oncology allow us to analyze the changes in body composition that occur during treatment and how these changes impact ...
Improved Preparative Chemical Methodologies to Address Challenging Targets: Synthetic, Semi-synthetic and Multicomponent Approaches
In the context of facilitated methodologies for the obtention of bioactive compounds, in this thesis we have explored the possibility of introducing reliable, pot-economic and semi-synthetic approaches in the quest of ...
Synthesis and development of bioactive compounds: soluble epoxide hydrolase inhibitors and antiviral molecules
The present Thesis is divided in three chapters: 1. Design and synthesis of new soluble epoxide hydrolase inhibitors (sEHI) The synthesis of new soluble epoxide hydrolase inhibitors based on ureas as the main ...
The Tousled-like kinases and their implications in cancer and neurodevelopmental disorders
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute to histone deposition ...
Identificación y caracterización de nuevos defectos del metabolismo energético mitocondrial asociados a aciduria 3-metilglutacónica y a deficiencia del complejo I
Las enfermedades del metabolismo energético mitocondrial son un grupo de patologías con una gran heterogeneidad clínica, bioquímica y genética. Aunque en la última década la implementación de las técnicas de “Next generation ...
Colloidal lipid gels: A novel approach to structure dispersions of lipids
Lipids are essential components in most living organisms whose functionality varies with their chemical structure. In an aqueous environment, diluted dispersions of phospholipids tend to form vesicles and other bilayered ...
Tris(triphenylphosphine)Ruthenium(II) dichloride: a versatile catalystin the synthesis of β-, γ- and δ-lactams from trichloroacetamides and in the isomerization of protected allylamines to Z-enamines under microwave activation
In this PhD thesis we have demonstrated that tris(triphenylphosphine)ruthenium(II) dichloride (RuCl2(PPh3)3) is a potent and versatile catalyst capable of achieving efficient different chemical transformations under microwave ...
Utilización de aceites ácidos y ácidos grasos destilados en alimentación animal: caracterización de estos subproductos y repercusiones de su uso en la estabilidad oxidativa de piensos y carne de pollo
La correcta formulación de piensos es esencial para conseguir dietas que aporten al animal niveles equilibrados de nutrientes, a la vez que se consiga una eficiencia en la producción animal mediante piensos con palatabilidad ...
Functional analysis of a phloem cysteine protease in Arabidopsis thaliana
Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite diverse, from ...
Population pharmacokinetic-pharmacodynamic modeling in solid organ transplantation: Basis of personalized immunosuppression
Despite advances in immunosuppression, allograft rejection and clinical outcomes remain a challenge in solid organ transplantation. Currently, the immunosuppressive treatment’s individual adjustment is guided by the ...
Nanotechnology-mediated strategies targeting cancer stem cells for advanced cancer treatment
Despite the latest advances in early diagnosis and increased resources employed to develop new therapeutic options, effective control of cancer disease remains a challenge. In fact, cancer is the second leading cause of ...
Polimedicación y Prescripción “off-label” del Paciente con Daño Cerebral Adquirido y Lesión Medular
OBJETIVOS: Describir y analizar la prevalencia de la polimedicación y de la prescripción “off-label” de los pacientes con daño cerebral adquirido (DC) y con lesión medular (LM) que estaban ingresados en un hospital de ...
Metal-dependent 2-oxoacid aldolases as versatile biocatalysts for the synthesis of chiral multifunctional compounds
Biocatalysis gained importance in the latter half of the 20th century and its application in the pharmaceutical, food and chemical industries continues to expand nowadays. Enzymes catalyze chemical reactions in a highly ...
Targeting non-canonical p38 MAPK signalling: discovery and characterization of novel allosteric p38α inhibitors
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α inhibitors are mainly ...
Health-promoting phenolic compounds in extra virgin olive oil: an integrated study of their concentration and bioavailability
The health promoting attributes associated with following a traditional Mediterranean diet have been reviewed extensively. The principal source of dietary fat in the Mediterranean diet is Extra virgin olive oil (EVOO) that ...
