Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 181-200 of 338
Role of the atypical CDK activator RINGO beyond meiosis
The cell cycle is orchestrated by the periodic activation of Cyclin-dependent kinases (CDKs). The enzymatic activity of CDKs depends on their association with cyclins, however, in some cases these kinases can be activated ...
Metabolismo de esteroles esterificados en plantas: implicación en el desarrollo y la respuesta a estrés
Los esteroles son una familia de compuestos triterpénicos que se presentan en forma libre o conjugada, como ésteres, glicósidos y acilglicósidos de esteroles. Cada especie vegetal tiene su propio perfil cualitativo y ...
Neuroblastoma cancer stem cells: The role of NXPH1 and its receptor α-NRXN1
Neuroblastoma (NB) is a devastating paediatric cancer that originates in the developing sympathetic nervous system. These tumours account for 40% of the cases of cancer diagnosed during the first year of life and 8% of the ...
Role of tRNA modifications in the synthesis of the extracellular matrix
Transfer RNAs (tRNAs) are key adaptor molecules that mediate decoding of messenger RNAs (mRNAs) into proteins by complementary pairing of their anticodons with mRNA codons. tRNAs that undergo adenosine to inosine editing ...
Desenvolupament i recerca de formulacions per a vacunes veterinàries
INTRODUCCIÓ: Aquesta tesi doctoral està inclosa dins del Pla de Doctorats Industrials de la Generalitat de Catalunya i s’ha realitzat conjuntament entre la Universitat de Barcelona i una empresa veterinària privada: ...
El problema de la no iniciación del tratamiento farmacológico: evaluación con métodos cualitativos
La no iniciación ocurre cuando se le prescribe un nuevo tratamiento farmacológico a un paciente y este, toma la decisión de no empezarlo. La prevalencia de no iniciación oscila entre el 6% y el 28% en atención primaria y ...
Gαq regulates mitochondrial motility and interacts with ALEX3, MIRO1 and TRAK proteins
G proteins transduce a myriad of signals from receptors at the plasma membrane. Recent reports point to a novel localization of G proteins at the mitochondria and other endomembranes where they regulate the physiology of ...
Active Liquid Crystals in Confinement
Living systems flow. What appears obvious from our daily observation of people, birds or insects remains surprisingly true at the smallest scale of life. Even at the earliest stages of embryonic development, the most ...
Structural insights into “acid blobs and negative noodles” – The androgen receptor as a case study
Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured negatively charged ...
Intervenciones nutricionales en la prevención cardiovascular y efectos de los factores de riesgo en el tejido adiposo
Las enfermedades cardiovasculares son una de las principales causas de mortalidad y morbilidad a nivel mundial, apareciendo como consecuencia de la acumulación de diversos factores de riesgo, tanto genéticos como ambientales. ...
Computational Study of the Structure and Dynamics of Androgen Receptor Polyglutamine Tract
Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative disorders called ...
Optical control of endogenous receptors and cellular excitability with light
Light-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons, one single ...
Estudi del paper de les proteïnes JNK en el desenvolupament de trastorns metabòlics i cognitius = Study on the role of the JNK proteins in the development of metabolic and cognitive disruptions
Molts estudis previs sobre el paper de les cinases c-JUN N-terminal (JNK) no tenien en compte les diferències existents en l’activitat de cadascuna de les isoformes. Això va provocar que les propostes terapèutiques que ...
The Role of Microtubule nucleation during neural development
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, in vicinity of the ...
Signal Transduction proteins in Streptococcus pneumoniae and Vibrio cholerae
The aim of this project is to structurally characterize proteins involved in bacterial signal transduction systems by applying X-ray crystallography. Bacteria use signal transduction systems to react in response to any ...
Caracterització morfològica i molecular i estudi epidemiològic d’espècies d’Anisakis i Hysterothylacium (Nematoda: Ascaridoidea) en peixos de consum habitual procedents de l’Atlàntic Nord-Est i del Mediterrani
Aquest treball engloba l’estudi d’espècies de nematodes ascaridoïdeus de les famílies Anisakidae i Raphidascarididae paràsites de peixos marins arreu del món que presenten un interès sanitari i/o comercial. Dins la família ...
Interactions between marine picoeukaryotes and their viruses one cell at a time = Interacciones entre picoeucariotas marinos y sus virus célula a célula
Marine viruses are key components of marine microbial communities, as they influence the cellular abundances and the community structure of microbes, participate in their genetic exchange, and intervene in the ocean ...
A role for heterochromatin and repetitive elements in epigenetic inheritance
Gene regulation mechanisms control the level of transcription of each gene into RNA and the combination of expressed genes determines cell identity. Gene regulation is maintained by epigenetic mechanisms including DNA ...
The supramolecular organization of cancer metabolism: From macromolecular crowding to metabolic reprogramming underlying cancer metastasis and drug resistance
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems biology and biophysical ...
IRBC-induced p53-dependent Cell Death in c-MYC-driven tumors mediated by loss of MCL1
The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that oncogenic MYC relies ...
