Universitat de Barcelona
Now showing items 1-20 of 80
[eng] In the last decades biological invasions have emerged as a global concern, as they impact local biodiversity by disrupting ecosystem functioning and ultimately affect human health, economy and wellness. In a climate ...
The tracheal (respiratory) system of the Drosophila embryo is a network of interconnected epithelial tubes that supplies and exchanges the gas to maintain the homeostasis of the entire organism. Maintaining a controlled ...
Histone H1 is a key determinant of higher-order chromatin structures and for a long time it has been considered a main transcriptional repressor. So consistent with its biochemical properties, the absence of histone H1 was ...
Seven linker histone H1 variants are present in human somatic cells with distinct prevalence across cell types. Using variant-specific antibodies to H1 and hemagglutinin-tagged recombinant H1 variants expressed in breast ...
In the Drosophila larva, most of the juvenile tissues are made up of large polyploid cells fated to die during metamorphosis stage. The dorsal trunk of the tracheal system is composed mainly of these cells, apart from the ...
La mayoría de las transacciones del genoma producen estrés topológico en el ADN, que se reduce gracias a la acción de las topoisomerasas. Por ejemplo, durante la transcripción y replicación del ADN, las topoisomerasas I y ...
La malaltia de von Willebrand (VWD) és la patologia hemorràgica hereditària més freqüent a la població i està causada per dèficits quantitatius o qualitatius del factor von Willebrand (VWF). Segons el defecte, es distingeixen ...
El objetivo global de esta tesis es ampliar el conocimiento sobre la biología y ecología del rorcual común, con foco principal en la población de rorcual común de Islandia. Dadas las numerosas incógnitas que siguen existiendo ...
Development requires an increment of cell growth and cell number, concomitant to a tightly control of cell differentiation. Thanks to cell communication, cells can be spatiotemporal patterned to acquire the required fate. ...
Animal multicellular structure depends on three general mechanisms: cell adhesion, cell communication and cell differentiation. Some of these mechanisms were thought to be specific to animals. Genome sequencing of unicellular ...
La vía Wnt canónica es una vía de señalización muy conservada a lo largo de la evolución de los animales. Esta vía controla múltiples procesos como es la especificación del eje anteroposterior o el destino celular durante ...
[eng] Inherited Retinal Dystrophies (IRDs) are a clinically and genetically highly heterogeneous group of genetic pathologies characterized by progressive attrition of photoreceptor cells and other retinal neurons, which ...
Melanoma is the malignant tumor arising from melanocytes and is the most aggressive of the common skin cancers. Melanoma is the tumor with the highest heritability (58%) and around 10% of cases occur in a familial context. ...
[eng] The study of tissue renewal in adult organisms has widely been viewed as a source to uncover the triggers for the disruption of cell lineages in pathologies such as cancer. One of pathways involved in this process ...
Chitin has a recognised importance in physiology but also as a biomaterial. In insects, it is the principal component of the apical extracellular matrix of epidermis, tracheae, foregut and hindgut. In these compartments, ...
Neurodevelopmental disorders (NDDs) are a group of chronic diseases in which the development of the central nervous system is impaired, resulting in disability at the neuropsychiatric, motor and/or intellectual level. Some ...
In this thesis we have covered the importance of finding underlying conservation events to better understand the regulatory mechanisms of important development orchestrators like the Hox cluster. As an example of these ...
The plant pathogen Ralstonia solanacearum is the causal agent of bacterial wilt, a highly aggressive disease responsible for important worldwide economic losses. Many virulence factors in R. solanacearum have been already ...
The regulation of the expression of virulence genes in Salmonella enterica serovar Typhimurium is an intensively studied feature of Salmonella lifestyle. How Salmonella integrates environmental signals to activate ...
The bloom of genomic data has revealed a vast amount of gene losses across all life kingdoms. However, the impact of gene loss on the evolution of the mechanisms of embryo development remains an important challenge. In ...
