A computational study of intervertebral disc degeneration in relation to changes in regional tissue composition and disc nutrition 

    Ruiz Wills, Carlos (Date of defense: 2015-07-17)

    Up to 85% of the world population suffers from low back pain, a clinical condition often related to the intervertebral disc (IVD) degeneration (DD). Altered disc cell nutrition affects cell viability and can generate ...

    Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration 

    Martí Muñoz, Joan (Date of defense: 2018-11-14)

    An insufficient vascularization of the wound site is often the cause of failure in tissue regeneration. The use of cell therapy or growth factors has introduced promising results, nevertheless, they are risky, expensive ...

    Effect of doping ions and organic molecules on the precipitation and biological interactions of nanostructured calcium phosphates 

    Zhao, Zhitong (Date of defense: 2015-11-20)

    From a chemical and structural point of view, hydroxyapatite (HA) is a strong candidate in biomedical applications owing to its similarity to the inorganic components of bones and teeth. HA nanoparticles (NPs) as colloidal ...

    Tuning the biological performance of calcium phosphates through microstructural and chemical modifications 

    Díez Escudero, Anna (Date of defense: 2017-11-13)

    Bone is the most transplanted tissue after blood. As pointed out by the World Health Organization, musculoskeletal diseases can potentially rise as the fourth largest cause of disability within the next years. Unfortunately, ...