Departament de Patologia i Terapèutica Experimental: Enviaments recents
Ara mostrant els elements 1-20 de 69
Modeling neuro-immune interaction in Parkinson’s disease using an iPSC-based autologous in vitro system
[eng] Parkinson’s disease (PD) is a chronic, incurable, progressive neurodegenerative disorder pathologically characterized by intracellular aggregates of α-synuclein (α-syn) forming Lewy bodies (LBs) and the loss of ...
Targeting TREX2: an innovative keratinocyte-based therapy for psoriasis and atopic dermatitis
[eng] The fact that TREX2 is specifically expressed on KCs, upregulated in psoriatic skin and its loss leads to a decreased inflammation in mice models of the disease, points TREX2 as a candidate target for new KC-based ...
Natural cannabinoids against Alzheimer’s disease: a role in glutamatergic regulation
[eng] Alzheimer's disease (AD), characterized by the loss of memory and other cognitive abilities, is the predominant form of dementia. Given the impact it has on individuals, affected families and health systems, it is ...
Ankle lateral instability: arthroscopic treatment strategy
[eng] - INTRODUCTION: A lateral ankle sprain is the most common injury to the lower extremity. It can cause chronic ankle instability (CAI) in 20 to 30% of cases with an impact on public health. Surgical treatment is ...
CB(1), A(2A) and D(2) receptors balance as a target against psychotic-like symptoms associated to Alzheimer’s disease and cannabis abuse
[eng] Psychosis is a mental health problem characterized by a loss of contact with reality, which is considered the defining feature of schizophrenia spectrum disorders. However, psychotic symptoms may occur in other medical ...
Super-Cationic peptides: insights on their antimicrobial action
[eng] Bacteria have been to the human civilization a threat as well as an ally, since the beginning of time. The introduction of antibiotics into clinics to treat infections was one of the best medical achievements ever ...
Streptococcus pneumoniae, resistance and disease in adults in the era of conjugate vaccines
[eng] Streptococcus pneumoniae is an important human pathogen, being one of the main etiological agents of serious infectious diseases such as pneumonia or meningitis and other less serious like otitis media. S. pneumoniae ...
Estudio de las resistencias a los fármacos y los mecanismos moleculares más frecuentes en Mycobacterium tuberculosis complex en España
[spa] En España, existe una monitorización insuficiente de la tuberculosis, no incluyendo en la declaración obligatoria la notificación de algunos datos relevantes del paciente y de laboratorio. Esta infra-notificación ...
Epidemiología y estudio de la dinámica poblacional en las infecciones por Staphylococcus aureus resistente a meticilina
[spa] Uno de los problemas de salud de más relevancia a nivel global es el de las infecciones por bacterias resistentes a los antibióticos. La Organización Mundial de la Salud (OMS) junto al Centro para el Control y la ...
Epidemiology, population structure, and pathogenesis of opportunistic respiratory tract colonising bacteria
[eng] The bacterial colonisation of the respiratory tract is critical for health as it establishes a symbiotic relationship between the bacterial community and the host. Haemophilus influenzae and Staphylococcus aureus are ...
Synaptic transmission in autaptic circuits: presynaptic homeostatic plasticity and microtubule dynamics
Synapses are the contact sites where the transfer of information from the presynaptic to the postsynaptic site occurs. Correct processing of information requires that synapses continuously adapt their properties to an ...
La senyalització purinèrgica en l'endometriosi. Paper en el teixit eutòpic i ectòpic
L’endometriosi és una malaltia ginecològica, associada a un component inflamatòri crònic, caracteritzada per la presència de teixit endometrial fora de l’úter. L’etiologia de la malaltia encara és manté incerta i el seu ...
Adenosine receptors in Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia affecting 1 of every 20 persons older than 65 years and 9% of the octogenarians, and extensive research efforts have been undertaken to identify molecular, ...
Outer membrane: a key obstacle for new antimicrobial agents
INTRODUCTION: Antimicrobial resistance is one of the world’s major challenges in both microbiology and public health since infections caused by multidrug-resistant bacteria are reaching alarming levels. The world is currently ...
Irrigation with Laser-Activated sodium hypochlorite: An antimicrobial alternative in endodontics
Bacteria and their sub-products are the main cause of the occurrence and perpetuation of endodontic infection. However, only a few bacterial species are seen as responsible of persistent endodontic infections, among them ...
Desarrollo de la podología en España
La Podología es una especialidad sanitaria que a lo largo de su desarrollo ha estado sometida a dualidades empíricas y científica, lo que ha originado que su evolución le haya relegado a un nivel supeditado a otras disciplinas ...
Experimental Approaches for Pulp Tissue Regeneration
The aim of this PhD thesis was to study experimental approaches for revitalization of necrotic teeth. Revitalization, also known as regenerative endodontic procedures (REPs), is a relatively new treatment for necrotic teeth ...
Canales de calcio y dolor: Investigación del mecanismo de acción de la pregabalina sobre la neurotransmisión
Los gabapentinoides son una familia de fármacos que se unen con gran afinidad a la subunidad α2δ-1 de los canales de calcio voltaje-dependientes (VGCCs). Fármacos de esta familia como la pregabalina o la gabapentina se ...
Synthetic Polymyxin-based Peptides Against Multidrug Resistant Bacteria: A Therapeutic Option
Pseudomonas aeruginosa and Staphylococcus aureus are nosocomial opportunistic pathogens causing a wide variety of both acute and chronic infections, such as pneumonia, bacteraemia, and urinary tract infections. Immunocompromised ...
Identification of a risk transcriptome and proteome in Parkinson’s disease, Dementia with Lewy bodies and rapidly progressive Dementia with Lewy bodies
Parkinson's disease (PD) is a neurodegenerative disorder characterized by movement impairment, or parkinsonism, for which there is still no cure. The manifest clinical signs result from neuronal loss of more ...
