Departament de Biologia: Recent submissions
Now showing items 21-40 of 124
Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada
Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...
Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent
INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...
Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification
Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...
Inhibition of sialyltransferases in pancreatic cancer: effects on the EGFR pathway and on the tumour phenotype
Pancreatic ductal adenocarcinoma (PDA) presents a dismal prognosis mainly due to its delayed diagnosis, its aggressiveness, and resistance to existing therapies. Aberrant glycosylation and, in particular, the overexpression ...
Caracterización de polimorfismos genéticos implicados con el metabolismo de la citarabina y asociación con la respuesta y toxicidad a la quimioterapia en pacientes con leucemia mieloide aguda de riesgo intermedio
Acute myeloid leukemia (AML) is adults' most common acute leukemia. Prognostic factors influencing treatment response and patient survival are diverse, the most relevant being those associated with specific cytogenetic and ...
Estudio del impacto de UGT2B17 y PD-1 en el trasplante alogénico de progenitores hematopoyéticos a partir de donante emparentado HLA idéntico
Study of the impact of UGT2B17 and PD-1 on allogeneic transplantation of hematopoietic progenitors (allo-TPH) from HLA-identical related donor. everal genetic factors can favor the development of graft-versus-host disease ...
Estudi de la reacció de trans-splicing i caracterització fisicoquímica de la inteïna partida Neq DNA polimerasa B de l'hipertermòfil N. equitans
Protein splicing is an autocatalytic process with different stages that involves the elimination of an internal sequence, called intein, from the precursor polypeptide chain and the formation of a peptide bond between ...
Estructura poblacional y conectividad genética de la gamba roja, Aristeus antennatus, en el Mar Mediterráneo noroccidental
The conservation of a commercially exploited species is fundamental to ensure the long-term sustainability of the resource. Thus, genetic information is essential for the identification of reproductively isolated and ...
Biomarcadors diagnòstics de disfunció miocàrdica associada a xoc sèptic: avaluació de la troponina T ultrasensible i de la hiperosmolalitat plasmàtica
La resposta inflamatòria d’un hoste pot ser excessiva o desregulada en relació a la intensitat o la durada d’una agressió. Quan aquesta resposta és secundària a una infecció es coneix com a sèpsia i pot acabar lesionant ...
Physiological role of mitochondrial and plasma membrane channels in sperm
The spermatozoon is a highly specialised cell that travels along the female reproductive tract to deliver its genetic information into the oocyte. During this journey, the interaction with the varying environment is crucial ...
Study of the anticancer activity of a nuclear directed HP-RNase variant and different metal-based compounds
Cancer is the leading cause of death due to non-communicable diseases worldwide. Despite the advances in the development of new antitumor drugs, there are still problems such as the resistance that tumor cells acquire ...
Algoritme diagnòstic en el laboratori. Impacte dels nous índex hematimètrics
Currently, automatic analyzers based on highly accurate methods can determine hematologic parameters in a fast and reliable way which is important to detect abnormalities in blood cells. In laboratories with a high care ...
Physiological role of sperm and seminal plasma proteins along the female reproductive tract in livestock
In Spain, as well as in the rest of Europe, livestock farming represents a substantial part of economy; thus, it is necessary to ensure an optimal breeding of the main farm animals, including swine and cattle. In order to ...
Importance of hydrogen-mediated mechanisms for microbial electrosynthesis: regulation at the molecular level
Microbial electrosynthesis (MES) is engineered to use electric power and carbon dioxide (CO2) as the only energy and carbon sources in reductive bioelectrochemical processes for biosynthesis. This technology is conducted ...
Signatures bacterianes com a eines de diagnòstic diferencial i monitoratge de les malalties inflamatòries intestinals
Inflammatory Bowel Disease (IBD) is a group of immune-based pathologies that affect the digestive tract, causing chronic inflammatory diseases processes. In recent years, the microbial communities that inhabit the human ...
Applying a sequential approach in order to detect and interpret a possible increased rate of myeloid malignancies in the Girona province
This thesis is aimed at demonstrating a sequential-based approach in detecting an epidemic of chronic diseases in small populations. Especially if commences at some unobserved point. Analyses encompassed registered cases ...
Monitoratge de la malaltia inflamatòria intestinal en la pràctica clínica mitjançant marcadors de la microbiota intestinal en mostres fecals. Estudi prospectiu
The gut microbiota (GM) plays a pivotal role in the maintenance of gut homeostasis, and the pathogenesis of inflammatory bowel disease (IBD) which includes Crohn's disease (CD) and ulcerative colitis (UC). The degree of ...
Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...
Genetics and transcriptomics of adherent-invasive Escherichia coli (AIEC): new approaches to uncover molecular markers for its rapid identification
The adherent-invasive Escherichia coli (AIEC) pathotype could play a role in the course of Crohn’s disease. This is characterized by its capacity to adhere to and to invade intestinal epithelial cells as well as to replicate ...
Physical performance and hamstring injury risk factors during the off-season period in footballers: inertial flywheel versus gravity-dependent resistance training methods
The physical demands (high-intensity running and sprinting) of football match-play place footballers at increased risk of hamstring injuries. Some of the negative effects of a hamstring injury such as neuromuscular ...
