Departament de Biologia: Recent submissions
Now showing items 41-60 of 124
Electrical stimulation of the medial forebrain bundle as a potential therapy for Alzheimer's disease: effects on molecular markers in rodent model
Electrical stimulation of deep brain areas has been suggested as a novel approach to restore memory circuits in Alzheimer’s disease (AD). Previous studies from our group have demonstrated that rewarding stimulation of the ...
Occurrence of antibiotic resistance genes in aquatic microbial communities exposed to anthropogenic activities
The overuse of antibiotics has led to the selection of resistant strains. This thesis investigated the occurrence of antibiotic resistance genes (ARGs) in aquatic microbial communities influenced by anthropogenic activities. ...
Microbial communities responses in fluvial biofilms under metal stressed scenarios
This thesis shows how the metals of natural and anthropic origin change significantly the composition of the prokaryotic communities (mainly the composition of bacteria). The β-diversity is the most sensitive variable to ...
Inter-limb asymmetries and sports performance: from assessment to the application of a sport-specific iso-inertial resistance training in young athletes
The asymmetries detected in the different multi-directional sports vary in magnitude depending on the test selected. Furthermore, in the individual analysis of the different tests administered, it was observed that athlete’s ...
Groin problems in male football: beyond the time-loss approach
This Thesis aimed at studying the prevalence and severity and broadening the knowledge of aetiology and risk factors of groin injuries in male football. The four papers, which form part of this Thesis, are based on the ...
Altered glycosylation in pancreatic cancer: development of new tumor markers and therapeutic strategies
Pancreatic Ductal Adenocarcinoma (PDA), the most common pancreatic cancer, remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. Expression ...
Desenvolupament d’una vacuna contra la mamitis bovina causada per Streptococcus uberis
Bovine mastitis caused by Streptococcus uberis is a major problem in the dairy industry worldwide. Despite of that, there is no vaccine commercial available against it. Therefore, the objectives of this doctoral thesis are ...
Towards the implementation of a biotechnology for biogas upgrading: role of bacteria in siloxane removal
Biogas is a highly recognized alternative to fossil fuels towards a sustainable energy production. Massive use of biogas depends on the removal of contaminants that may affect performance of processing equipment and energy ...
Development of new, non-invasive tools based on faecal bacterial signatures for the early detection of colorectal cancer
This thesis aims to develop a new non-invasive tool based on faecal bacterial markers for the early detection of colorectal cancer, which is capable of detecting precancerous lesions before the onset of clinical signs. ...
Efecte de l'administració de l'rt-PA en condicions isquèmiques in vitro i in vivo: Cav-1 com a potencial biomarcador de volum d'infart
Recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for the treatment of acute ischaemic stroke. However, the application of this therapy is limited to <5-7% of patients due to the ...
Estudi de la funció del factor de transcripció StNAC103 en el fel·lema
The results obtained in this thesis indicate that StNAC103 promoter activity is induced in tissues undergoing suberin synthesis. Moreover StNAC103 transcript accumulation is concomitant to that of CYP86A33 and takes place ...
Identificació de gens i processos rellevants pel fel·lema i la suberina usant noves aproximacions
The periderm is a complex structure that protects plants’ secondary organs and wounded tissues. This function is given by the phellem, a multilayered tissue formed by cells with suberized cell walls located on the outer ...
Desenvolupament i aplicació dels microsatèl·lits a l'estudi de la dinàmica reproductiva de la Gamba rosada (Aristeus antennatus)
The blue and red shrimp, Aristeus antennatus, is a commercially important crustacean in the Western Mediterranean Sea and has been listed as a priority species for fishery management. In this thesis, 97 potential and novel ...
Estudi de l'activitat antitumoral de nous compostos basats en metalls de transició
Nowadays, cancer is one of the leading causes of death in developed countries. Therefore, there is great interest of developing new therapeutic strategies to improve the efficiency of current cancer treatments. The ...
Aquaporins in boar and bull spermatozoa: identification and functional implications
Aquaporins (AQPs) are proteins involved in the transport of water and some other solutes across plasma membranes. The fact that mammalian spermatozoa are highly permeable to water suggests the presence of these proteins. ...
Diversity, dynamics and activity of Epsilonproteobacteria in a stratified karstic lake. Implications in carbon and sulfur cycles
This doctoral thesis studies the abundance, diversity, seasonal dynamics and activity of Epsilonproteobacteria in a meromictic basin of Lake Banyoles during three year cycles. We applied a complementary array of molecular ...
Freezability markers for boar sperm: new proteomic approaches
Sperm cryopreservation is currently the most suitable technique to store boar sperm samples for a long period of time. However, not all boar ejaculations present the same freezability, this allows the classification of ...
Functional genomics of the periderm: the biosynthetic gene FHT, the transcriptional regulator StRiK and the transcriptome deciphering
We have developed new molecular tools to characterize the FHT and StRIK genes in the tuber periderm. Regarding FHT gene, our results demonstrated that is induced very specifically in suberizing tissues what makes FHT a ...
Genetic characterization of the Iberian populations of two invasive mollusks: zebra mussel and asiatic clam
The zebra mussel and the Asian clam are two invasive aquatic species worldwide. Both species are present in the Iberian Peninsula for several years. However, introduction history and colonization routes of these two invasive ...
Estudis bioquímics i moleculars en pacients amb deficiències mitocondrials i de coenzim Q10
The diagnose of a mitochondrial disease implies biochemical studies such as the enzymatic activities of the mitochondrial respiratory chain (MRC) and the quantification of the amount of CoQ10 in energetic tissues. Throughout ...
