Departament de Biologia: Recent submissions
Now showing items 61-80 of 124
Bacteriospermia and porcine reproduction: effects on sperm quality and fertility potential of boar spermatozoa
Boar semen is not collected under sterile conditions,so boar ejaculates are commonly contaminated with a broad range of microorganisms, which may affect sperm quality and lead to a low reproductive performance and severe ...
Anàlisi de la selectivitat per a cèl·lules tumorals de ribonucleases citotòxiques i desenvolupament d'eines per augmentar aquesta selectivitat
Les ribonucleases són enzims que presenten citotoxicitat selectiva per a cèl·lules tumorals. S'ha proposat l’ús de ribonucleases dirigides a nucli (ND-RNases) com a fàrmacs antitumorals. En aquest treball s'ha caracteritzat ...
Structural and functional characterization of Apoptin and design of a monomeric variant with antitumor activity
The main aim of the present study is to characterize the biological and biophysical properties of Apoptin, a viral protein that selectively induces apoptosis of a wide range of tumor cells. Apoptin has been produced and ...
Pancreatic cancer markers based on aberrant glycosylation of serum proteins
Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest ...
From inocula to biological reactors: molecular characterization of N-cycle bacterial assemblages in a PANAMMOX process
Nowadays, the combination of the autotrophic nitrification together with heterotrophic denitrification is the most common process for N-removal in the WWTPs. However, when the C:N ratio is low, this two-step process does ...
Antitumoral properties of epidermal growth factor derivatives
The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that ...
Ecophysiology and philogeny of Faecalibacterium prausnitzii in healthy and diseased gut. Application in Inflamatory Bowel Disease diagnostics
In this PhD thesis Faecalibacterium prausnitzii populations of patients with gut disease and healthy individuals have been characterized. First, isolates from healthy volunteers have been phenotypically characterised, ...
Flora i vegetació a l'Alta Garrotxa
Hem dut a terme l'estudi de la flora i la vegetació de la l'Alta Garrotxa, territori situat a la part oriental de la serralada pirinenca que abasta aproximadament les terres compreses entre el curs mitjà del riu Fluvià i ...
Genetic diversity and population structure of the non-native Eastern mosquitofish (Gambusia holbrooki) in Mediterranean streams
Mosquitofish is a small, voracious, highly fecund freshwater fish species originated from northeaster America, that was introduced worldwide to control mosquito populations. In this thesis we have studied the genetics of ...
Bioenergetics mechanism and autophagy in breast cancer stem cells
Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics de les cèl•lules mare ...
Disseny, construcció i caracterització de zimògens de ribonucleases
El disseny i la producció de zimògens de ribonucleases que puguin ser específicament activats per la proteasa d’un patogen, constitueix un enginyós mecanisme per controlar la seva activitat enzimàtica i, conseqüentment, ...
Estudis cinètics i estructurals de la trans inteïna Npu DnaE de "Nostoc punctiforme"
Les inteïnes són dominis proteics que mitjançant un procés de tall i unió s’autoescindeixen de la cadena polipeptídica precursora i catalitzen la unió de les seqüències flanquejants (exteïnes) mitjançant un enllaç peptídic. ...
Regulation and function of silayltransferases in pancreatic cancer
Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and ...
Anàlisi de la vehiculització de compostos metàl·lics com a agents antitumorals i de la família HER-EGF en la resistència als tractaments oncològics
Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these limitations through ...
Molecular mechanism of PE5-induced cytotoxicity and generation of new cytotoxic nuclear-directed
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
In vitro production of porcine embryos. New insights into optimization of culture media with relevance to sex ratio purposes
This thesis is about challenges that currently concern in vitro production (IVP), sex determination procedures and sex-related survival of in vitro-produced porcine embryos. Specifically, the current thesis develops a new ...
Vitrification of in vitro produced porcine blastocysts: the effects of culture medium and antioxidants
In the present Thesis, we observed that vitrifying-warming porcine embryos had detrimental effects. Indeed, vitrification and warming were seen to reduce developmental ability and quality of in vitro produced porcine ...
Caracterització de determinants estructurals de propietats especials de la ribonucleasa pancreàtica humana
Ribonucleases are promising candidates for use in anticancer therapy. There are different ways to endow an RNase with antitumor properties. Targeting the enzyme to the cell nucleus is a potential approach. PE5 is a variant ...
Nous mecanismes de resistència primària al trastuzumab (Herceptin): bases moleculars per a la determinació d'un nou subtipus de càncer de mama (Basal/ErbB2+)
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
Phylogeographical analysis of two aristed shrimps, Aristeus antennatus and Aristaemorpha foliacea (Crustacea: Aristeidae), with implications for resource conservation
The conservation of species relies on a deep knowledge of biology of the species concerned, as well as on the identification of reproductively isolated units, which are genetically different from one other (genetic stocks). ...
