Departament de Genètica, Microbiologia i Estadística: Envíos recientes
Mostrando ítems 61-80 de 124
Quantitative proteomic approaches for the characterization of bacterial wilt resistance mechanisms in tomato. lnsights on the role of P69 subtilisin-like proteases in defense
The plant pathogen Ralstonia solanacearum is the causal agent of the devastating disease known as bacterial wilt. This disease affects more than 200 plant species in over 50 families, including economically important crops ...
Sea turtle conservation: genetics and genomics for a better management
Conservation actions aim to preserve and recover animal and plant species using in-situ or ex- situ strategies. The first, aims to protect and sustain populations in their natural habitat, the second are implemented when ...
Targeting the TGF-beta pathway of cancer-associated fibroblasts in colorectal cancer metastasis
Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which there are no effective ...
Characterization of emerging novel human astrovirus: form bedside to bench
Novel human astrovirus (HAstV) are enteric virus belonging to the Astroviridae family and were discovered 10 years ago by high-throughput sequencing. They are divided in two different clades, the HAstV-MLB including 3 ...
Autonomous and non-autonomous regulation on planarian growth and regeneration: Smed-bls, canonical Wnt signalling and Fox family
Development requires an increment of cell growth and cell number, concomitant to a tightly control of cell differentiation. Thanks to cell communication, cells can be spatiotemporal patterned to acquire the required fate. ...
Genómica de la adaptación en artrópodos: estudio del sistema quimiosensorial y de la radiación del género Dysdera (Araneae) en Canarias
Los artrópodos, durante su historia evolutiva, han colonizado múltiples y diversos hábitats, incluyendo eventos de terrestrialización independientes en los distintos subfilos, e implicando en algunas ocasiones radiaciones ...
Desarrollo y utilización de herramientas bioinformáticas en el estudio de datos de secuenciación masiva: Análisis genómicos en arácnidos.
Encontramos una gran cantidad de información genómica en bases de datos para numerosos organismos pero existe un sesgo hacia ciertos grupos taxonómicos por el interés económico, social o sanitario. Los avances y el ...
Conservation of different mechanisms of Hox cluster regulation within chordates
In this thesis we have covered the importance of finding underlying conservation events to better understand the regulatory mechanisms of important development orchestrators like the Hox cluster. As an example of these ...
Identification and functional characterization of genetic loci involved in osteoporosis and atypical femoral fracture
Osteoporosis is a complex disease, determined by genetic and environmental factors, characterized by a low bone mass and microarchitectural deterioration of bone tissue, with a consequent decrease of bone strength and ...
Population genomics, phylogeographic history, and evolutionary patterns in Antartic shallow-water benthic invertebrates
Benthic organisms inhabiting the shallow waters of the Southern Ocean are considered excellent models to study evolutionary processes, population connectivity patterns, and adaptation. They have evolved in an extreme ...
Desarrollo de técnicas bioinformáticas para el análisis de datos de secuenciación masiva en sistemática y genómica evolutiva: Aplicación en el análisis del sistema quimiosensorial en artrópodos
Las tecnologías de secuenciación de próxima generación (NGS) proporcionan datos potentes para investigar cuestiones biológicas y evolutivas fundamentales, como estudios relacionados con la genómica evolutiva de la adaptación ...
Understanding the processes that shape the genetic diversity of freshwater planarians (Platyhelminthes, Tricladida, Dugesiidae) = Estudi dels processos que modelen la diversitat genètica en les planàries d'aigua dolça (Platyhelminthes, Tricladida, Dugesiidae)
The main goal of the present thesis has been to shed light into the processes that shape the genetic diversity of organisms, focussing in the following factors: the type of reproduction, the morphological diversity of ...
Selective killing of Ras-malignant tisues by exploiting oncogene-induced DNA damage = Eliminación selectiva de tejidos malignos dependientes de RAS mediante la explotación del daño en el ADN inducido por oncogenes
Most human solid tumors present signs of genomic instability. Activated oncogenes have been proposed to induce genomic instability through the generation of replicative stress. In this thesis, we have sown that the expression ...
Molecular determinants of human oocyte quality in assisted reproduction
Infertility, defined by the World Health Organization (WHO) as the inability to conceive after a year of unprotected sex, is a disease that affects 1 in 9 couples of reproductive age worldwide. Most of these couples will ...
Role of the histone demethylase PHF2 during early neurogenesis
During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...
Análisis del anudamiento del ADN intracelular
La mayoría de las transacciones del genoma producen estrés topológico en el ADN, que se reduce gracias a la acción de las topoisomerasas. Por ejemplo, durante la transcripción y replicación del ADN, las topoisomerasas I y ...
Aplicació de les noves tecnologies de seqüenciació massiva al diagnòstic molecular de la malaltia de von Willebrand. Estudi de grans cohorts i anàlisi de la correlació genotip-fenotip
La malaltia de von Willebrand (VWD) és la patologia hemorràgica hereditària més freqüent a la població i està causada per dèficits quantitatius o qualitatius del factor von Willebrand (VWF). Segons el defecte, es distingeixen ...
The regulatory landscape of Drosophila imaginal disc regeneration
One of the most important questions in regenerative biology is how and when genes change expression to trigger regeneration programs. Resetting of gene expression patterns during injury responses is shaped by the coordinated ...
Genètica i dependència de cocaïna: Estudis d'associació, transcriptòmica i models animals
La cocaïna és una droga psicoestimulant que actua directament sobre sistema de recompensa del cervell tot produint sensació de plaer. A més, els seus efectes sobre altres àrees cerebrals produeixen alteracions en l’estat ...
Epidemiologia molecular dels brots de gastroenteritis per norovirus i d'hepatitits A: de la seqüència consens a la quasiespècie
Dos dels virus entèrics humans més rellevants en l’àmbit de la salut pública i la seguretat alimentària són els HuNoV, causants de gastroenteritis aguda (GEA) esporàdica i epidèmica, i l’HAV, la principal causa d’hepatitis ...
