Universitat Pompeu Fabra
La UPF és una universitat pública, internacional i intensiva en recerca que està al nivell de les millors universitats europees. Amb excel·lents indicadors de producció científica com és el cas de les tesis doctorals en accés obert.
Si sou doctor o doctora de la Universitat Pompeu Fabra i voleu publicar la vostra tesi a TDX, contacteu amb CAU . Per a més informació consulteu Publicació de tesis a TDX. i les preguntes més freqüents
Selection forces have shaped the current human DNA sequence through evolution. These forces have been consistently changing, in magnitude and direction, across the different evolutionary episodes of the extant human ...
Type 1 Diabetes (T1D) is an autoimmune disease marked by the selective destruction of pancreatic β cells. Early insulitis involves interactions between immune cells and β cells, but the mechanisms leading to β cell death ...
In this thesis we study cell behaviours such as cellular decision making and self-organization using the developing mouse embryo as the system of study. To be able to extract the most needed cellular dynamics from ...
X-chromosome dosage compensation in female mammals is achieved through X-chromosome inactivation (XCI), where one X chromosome is epigenetically silenced to ensure dosage parity with male cells. During germline development, ...
Recent studies have shown that clones harboring cancer driver mutations colonize our tissues as we age. It remains to be determined whether the same is true for epigenetic alterations, specifically DNA methylation (DNAm) ...
Los trastornos neurodegenerativos como la enfermedad de Parkinson (EP) implican la degeneración progresiva del sistema nervioso, lo que provoca alteraciones tanto motoras como cognitivas. La EP afecta a millones de personas ...
During cellular differentiation, gene regulatory elements (GREs) play a crucial role in converting expression gradients of transcription factors (TF) into precise target gene activation. However, the underlying rules are ...
Interferon is essential for eliciting adaptive immunity against cancer cells. Type I interferon (IFNI) activates proinflammatory responses in dendritic cells (DCs) and this promotes specific anti-tumor T cell responses. ...
Advancements in machine learning have revolutionized various aspects of drug discovery, from molecular property prediction to de novo design. This thesis presents a comprehensive exploration of equivariant graph neural ...
La alteración de la barrera hematoencefálica está relacionada con la malaria cerebral, una complicación de la infección por Plasmodium falciparum asociada con la acumulación del parásito en los vasos sanguíneos cerebrales. ...
Molecular properties are highly important in drug discovery with binding affinity being crucial for selecting hit and lead candidates. Existing machine learning models often lack speed for large-scale screening or lack ...
La bifurcación entre trofoectodermo y la masa celular interna es la decisión de desarrollo más temprana, pero cómo se inicia y en qué etapa embrionaria ocurre no se entiende completamente. Aquí describimos que el factor ...
Fragile X syndrome (FXS), the most common monogenic cause of intellectual disability and autism, is characterized by impairment in cognitive function and synaptic plasticity. Several preclinical studies in animal models ...
El linfoma folicular (LF) es el subtipo más frecuente de linfoma no-Hodgkin indolente, caracterizado por un buen pronóstico a pesar de considerarse incurable. Sin embargo, algunos pacientes presentan un curso clínico más ...
Myocardial infarction (MI) remains a leading cause of mortality, with currently available treatments addressing symptoms rather than promoting heart muscle regeneration. Cardiac regeneration strategies, inspired by ...
The expansion of the Roman Empire throughout the Mediterranean region and West Eurasia severely shaped the world culturally and politically. This period has been traditionally studied and researched by historians and ...
This PhD thesis investigates the relationship between temperature and mortality at different spatial and temporal scales, addressing a crucial issue in the context of rising temperatures due to anthropogenic climate change. ...
The resilience of proteins against degradation makes them the longest surviving resource for genomic information. Knowing how much information we can obtain from an ancient sample is crucial because most sampling strategies ...
In breast cancer, the tumor microenvironment includes adipocytes and fibroblasts. When in contact with breast tumor cells, adipocytes undergo lipolysis and dedifferentiation. This thesis demonstrates that cancer-associated ...
This thesis investigates the integration and analysis of OMICs data to enhance in silico modelling of real-world patients, with a special focus on prostate cancer. By leveraging publicly available transcriptomics data, ...
575 - Genética general. Citogenética general. Inmunogenética. Evolución. Filogenia (310)
576 - Biología celular y subcelular. Citología (195)
577 - Bioquímica. Biología molecular. Biofísica (161)
614 - Higiene y salud pública. Contaminación. Prevención de accidentes. Enfermería (117)
